منابع مشابه
Suicide Gene Therapy against Cancer
A major limitation of conventional chemotherapies used in cancer treatments today are low therapeutic indices and side effects that result from drug effects on normal tissues (off target). One of the most innovative approaches to developing antineoplastic agents with increased tumor selectivity is the use of suicide gene therapy. Suicide gene therapy involves delivering a gene product in proxim...
متن کاملSuicide Gene Therapy for Cancer - Current Strategies.
Current cancer treatments may create profound iatrogenic outcomes. The adverse effects of these treatments still remain, as the serious problems that practicing physicians have to cope with in clinical practice. Although, non-specific cytotoxic agents constitute an effective treatment modality against cancer cells, they also tend to kill normal, quickly dividing cells. On the other hand, therap...
متن کاملAn Enterovirus-Like RNA Construct for Colon Cancer Suicide Gene Therapy
Background: In gene therapy, the use of RNA molecules as therapeutic agents has shown advantages over plasmid DNA, including higher levels of safety. However, transient nature of RNA has been a major obstacle in application of RNA in gene therapy. Methods: Here, we used the internal ribosomal entry site of encephalomyocarditis virus and the 3’ non-translated region of Poliovirus to design an en...
متن کاملEnhancement of HSV-TK/GCV suicide gene therapy of cancer
Gene therapy has become a promising alternative treatment form for cancer. Among the broad range of different genetic means to reduce the tumor growth, herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) suicide gene therapy regimen is the best known approach. In this type of therapy, cancer cells are manipulated to express HSV-TK, followed by administration of the prodrug, the antiv...
متن کاملMethioninase cancer gene therapy with selenomethionine as suicide prodrug substrate.
In this study, we report a novel approach to gene-directed enzyme prodrug therapy for cancer. This gene therapy strategy exploits the toxic pro-oxidant property of methylselenol, which is released from selenomethionine (SeMET) by cancer cells with the adenoviral-delivered methionine alpha,gamma-lyase (MET) gene cloned from Pseudomonas putida. In MET-transduced tumor cells, the cytotoxicity of S...
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ژورنال
عنوان ژورنال: Journal of Genetic Syndromes & Gene Therapy
سال: 2013
ISSN: 2157-7412
DOI: 10.4172/2157-7412.1000187